Graduate School of Informatics

Glioblastoma, the most aggressive type of the glial tumours, is thought to be widely promoted by stem-like cells. Liu et al. demonstrate that treatment Glioblastoma Stem Cells (GSCs) with Receptor Tyrosine Kinase inhibitors led to dynamic interconversion from proliferative to slow-cycling, persistent state. In this work, we use the publicly available RNA-seq and ChIP-seq data in naive patient-derived glioblastoma cell line (GSC8), 12-day and chronic dasatinib treated GSC8 and apply an integrative approach to develop a further explanation for reversible transition of GSCs and to model the effecMet of the dasatinib treatment in a network context.