Research News

M.S. Thesis
Integrative Network Modeling of the Dasatinib Treatment in Glioblastoma Stem Cells by Gökçe Senger

Glioblastoma, the most aggressive type of the glial tumours, is thought to be widely promoted by stem-like cells. Liu et al. demonstrate that treatment Glioblastoma Stem Cells (GSCs) with Receptor Tyrosine Kinase inhibitors led to dynamic interconversion from proliferative to slow-cycling, persistent state. In this work, we use the publicly available RNA-seq and ChIP-seq data in naive patient-derived glioblastoma cell line (GSC8), 12-day and chronic dasatinib treated GSC8 and apply an integrative approach to develop a further explanation for reversible transition of GSCs and to model the effecMet of the dasatinib treatment in a network context.