Ph.D. Candidate: Esra Nalbat
Program: Health Informatics
Date: 24.04.2023 / 10:30
Place: A-212

Hepatocellular carcinoma (HCC) is a type of primary liver cancer that is highly lethal and needs better treatment options. The thesis identifies several drugs and drug combinations that show promise in targeting drug-resistant HCC cells and cancer stem cells based on in silico modeling and in vivo experiments. It found that a combination of Sunitinib and Chloroquine Phosphate is synergistically cytotoxic on HCC cells, while novel isoxazole-piperazine compounds also show bioactivities against HCC cells and cancer stem cells. The study presents significant findings that highlight the potential of repurposed drugs and novel compounds as drug candidates for HCC.