Cancer System Biology Laboratory (CanSyL), is a research facility for cancer studies and cancer bioinformatics at the systems level. Recent WHO-IARC data reports that cancer is the major cause of morbidity and mortality (GLOBOCAN-2014) world wide. Cancer is a complex disease, defined by uncontrolled proliferation and spreading of abnormal cells. As a result, cancer tissue includes cell groups with different molecular characteristics, which contributes to tumor and patient heterogeneity. Therefore, systems biology approaches targeting complexity of cancer cells using experimental and computational methods are the main goal of CanSyL, by integrating, and applying interdisciplinary methods. We aim to gain a systems view of cancer biology and to develop computational tools that would be used in patient-specific diagnosis prognosis and treatment for this deadly disease. Thus, it will be possible to produce solutions for cancer risk prediction, diagnosis, treatment and follow-up purposes.

Group Members

Principle Investigators 

Asst. Prof. Dr. Aybar Can Acar

Affiliated Faculty Members

Assoc. Prof. Dr. Yesim Aydin Son

Assoc. Prof. Dr. Tunca Dogan

Assoc. Prof. Dr. Nurcan Tuncbag

Prof. Dr. Yasemin Yardimci Cetin

Former Principle Investigators 

Prof. Dr. Rengul Cetin-Atalay

Sponsored Projects

CanSyL: Cancer Systems Biology Laboratory, Ministry of Development, 2016-2019, (2 000 000 USD)

Possible Anti-cancer activities of Isocsasol Derivatives, Scientific and Technical Research Council of Turkey, 2015-2017, (150 000 USD)

Identification of cancer stem cell ratio in cancerous tissue microscopic images and development of automatic prediction tool to be used in clinics, Scientific and Technical Research Council of Turkey, 2014-2016 (~$300 000)

Chemical Approaches to Targeting Drug Resistance in Cancer Stem Cells (COST-StemChem), Scientific and Technical Research Council of Turkey, 2014-2017 (~$200 000) 

Intensified Cooperation (IntenC) “Düşük Maliyetli Bilgisayar Destekli Mikroskopik İşleme Sistemleri Ve Uygulamalar 'Locamssa'”, Scientific and Technical Research Council of Turkey,  2014-2015 (~$115 000)

Modeling of the effect of the PI3K/AKT kinase inhibitors on the cell signaling pathways using microarray data in liver cancer cells, Scientific and Technical Research Council of Turkey, 2011-2014 ($200 000)