Evrim Fer, Testing Natural Selection on Polygenic Trait-Associated Alleles in Anatolia Using Neolithic and Present-Day Human Genomes
Neolithic transition which has started approximately 10,000 year ago in west Eurasia and created a major shifts in human life. In many studies, strong selection signals on the genes related to changes in life-style were determined. With the advent of archeogenomics studies, those adaptations have also been supported using ancient DNA. Here, polygenic adaptations in Anatolia were investigated by comparing Neolithic (n=36) and modern-day (n=16) genome sequences for 40 polygenic traits potentially associated with diet, immunity and other related complex traits using pairwise FST and population branch statistics (PBS) method which provides a genome-wide selection analysis including a distant population.
Date: 29.07.2019 Place: A-212